Evidence accumulation detected in BOLD signal using slow perceptual decision making

Title:
Evidence accumulation detected in BOLD signal using slow perceptual decision making
Authors:
Krueger, Paul M.; van Vugt, Marieke K.; Simen, Patrick; Nystrom, Leigh; Holmes, Philip; Cohen, Jonathan D.
Abstract:
BACKGROUND: We assessed whether evidence accumulation could be observed in the BOLD signal during perceptual decision making. This presents a challenge since the hemodynamic response is slow, while perceptual decisions are typically fast. NEW METHOD: Guided by theoretical predictions of the drift diffusion model, we slowed down decisions by penalizing participants for incorrect responses. Second, we distinguished BOLD activity related to stimulus detection (modeled using a boxcar) from activity related to integration (modeled using a ramp) by minimizing the collinearity of GLM regressors. This was achieved by dissecting a boxcar into its two most orthogonal components: an "up-ramp" and a "down-ramp." Third, we used a control condition in which stimuli and responses were similar to the experimental condition, but that did not engage evidence accumulation of the stimuli. RESULTS: The results revealed an absence of areas in parietal cortex that have been proposed to drive perceptual decision making but have recently come into question; and newly identified regions that are candidates for involvement in evidence accumulation. COMPARISON WITH EXISTING METHODS: Previous fMRI studies have either used fast perceptual decision making, which precludes the measurement of evidence accumulation, or slowed down responses by gradually revealing stimuli. The latter approach confounds perceptual detection with evidence accumulation because accumulation is constrained by perceptual input. CONCLUSIONS: We slowed down the decision making process itself while leaving perceptual information intact. This provided a more sensitive and selective observation of brain regions associated with the evidence accumulation processes underlying perceptual decision making than previous methods.
Citation:
Krueger, Paul M., Marieke K. van Vugt, Patrick Simen, et al. 2017. "Evidence accumulation detected in BOLD signal using slow perceptual decision making." Journal of Neuroscience Methods 281: 21-32.
Publisher:
Elsevier
DATE ISSUED:
2017-04-01
Department:
Neuroscience
Type:
Article
PUBLISHED VERSION:
10.1016/j.jneumeth.2017.01.012
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0165027017300183
PERMANENT LINK:
http://hdl.handle.net/11282/620519

Full metadata record

DC FieldValue Language
dc.contributor.authorKrueger, Paul M.en
dc.contributor.authorvan Vugt, Marieke K.en
dc.contributor.authorSimen, Patricken
dc.contributor.authorNystrom, Leighen
dc.contributor.authorHolmes, Philipen
dc.contributor.authorCohen, Jonathan D.en
dc.date.accessioned2017-09-15T12:53:06Z-
dc.date.available2017-09-15T12:53:06Z-
dc.date.issued2017-04-01-
dc.identifier.citationKrueger, Paul M., Marieke K. van Vugt, Patrick Simen, et al. 2017. "Evidence accumulation detected in BOLD signal using slow perceptual decision making." Journal of Neuroscience Methods 281: 21-32.en
dc.identifier.issn0165-0270-
dc.identifier.urihttp://hdl.handle.net/11282/620519-
dc.description.abstractBACKGROUND: We assessed whether evidence accumulation could be observed in the BOLD signal during perceptual decision making. This presents a challenge since the hemodynamic response is slow, while perceptual decisions are typically fast. NEW METHOD: Guided by theoretical predictions of the drift diffusion model, we slowed down decisions by penalizing participants for incorrect responses. Second, we distinguished BOLD activity related to stimulus detection (modeled using a boxcar) from activity related to integration (modeled using a ramp) by minimizing the collinearity of GLM regressors. This was achieved by dissecting a boxcar into its two most orthogonal components: an "up-ramp" and a "down-ramp." Third, we used a control condition in which stimuli and responses were similar to the experimental condition, but that did not engage evidence accumulation of the stimuli. RESULTS: The results revealed an absence of areas in parietal cortex that have been proposed to drive perceptual decision making but have recently come into question; and newly identified regions that are candidates for involvement in evidence accumulation. COMPARISON WITH EXISTING METHODS: Previous fMRI studies have either used fast perceptual decision making, which precludes the measurement of evidence accumulation, or slowed down responses by gradually revealing stimuli. The latter approach confounds perceptual detection with evidence accumulation because accumulation is constrained by perceptual input. CONCLUSIONS: We slowed down the decision making process itself while leaving perceptual information intact. This provided a more sensitive and selective observation of brain regions associated with the evidence accumulation processes underlying perceptual decision making than previous methods.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.identifier.doi10.1016/j.jneumeth.2017.01.012-
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0165027017300183en
dc.subject.departmentNeuroscienceen_US
dc.titleEvidence accumulation detected in BOLD signal using slow perceptual decision makingen_US
dc.typeArticleen
dc.identifier.journalJournal of Neuroscience Methodsen
dc.subject.keywordEvidence accumulationen_US
dc.subject.keywordDrift-diffusion modelen_US
dc.subject.keywordDecision makingen_US
dc.subject.keywordFunctional magnetic resonance imagingen_US
dc.rightsArchived with thanks to Journal of Neuroscience Methodsen
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