Luteinizing hormone acts at the hippocampus to dampen spatial memory

Title:
Luteinizing hormone acts at the hippocampus to dampen spatial memory
Authors:
Burnham, Veronica L.; Sundby, Christopher; Laman-Maharg, Abigail; Thornton, Janice
Abstract:
Luteinizing hormone (LH) rises dramatically during and after menopause, and has been correlated with an increased incidence of Alzheimer's disease and decreased memory performance in humans and animal models. To test whether LH acts directly on the dorsal hippocampus to affect memory, ovariectomized female rats were infused with either the LH-homologue human chorionic gonadotropin (hCG) or the LH receptor antagonist deglycosylated-hCG (dg-hCG). Infusion of hCG into either the lateral ventricle or the dorsal hippocampus caused significant memory impairments in ovariectomized estradiol-treated females. Consistent with this, infusion of the LH antagonist dg-hCG into the dorsal hippocampus caused an amelioration of memory deficits in ovariectomized females. Furthermore, the gonadotropin-releasing hormone antagonist Antide, failed to act in the hippocampus to affect memory. These findings demonstrate a significant role for LH action in the dorsal hippocampus in spatial memory dysfunction.
Citation:
Burnham, Veronica, Christopher Sundby, Abigail Laman-Maharg, and Janice Thornton. 2017. "Luteinizing hormone acts at the hippocampus to dampen spatial memory." Hormones and Behavior 89: 55-63.
Publisher:
Elsevier for Academic Press
DATE ISSUED:
2017-03
Department:
Neuroscience
Type:
Article
PUBLISHED VERSION:
10.1016/j.yhbeh.2016.11.007
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0018506X16302124
PERMANENT LINK:
http://hdl.handle.net/11282/620490

Full metadata record

DC FieldValue Language
dc.contributor.authorBurnham, Veronica L.en
dc.contributor.authorSundby, Christopheren
dc.contributor.authorLaman-Maharg, Abigailen
dc.contributor.authorThornton, Janiceen
dc.date.accessioned2017-09-12T18:22:05Z-
dc.date.available2017-09-12T18:22:05Z-
dc.date.issued2017-03-
dc.identifier.citationBurnham, Veronica, Christopher Sundby, Abigail Laman-Maharg, and Janice Thornton. 2017. "Luteinizing hormone acts at the hippocampus to dampen spatial memory." Hormones and Behavior 89: 55-63.en
dc.identifier.issn0018-506X-
dc.identifier.urihttp://hdl.handle.net/11282/620490-
dc.description.abstractLuteinizing hormone (LH) rises dramatically during and after menopause, and has been correlated with an increased incidence of Alzheimer's disease and decreased memory performance in humans and animal models. To test whether LH acts directly on the dorsal hippocampus to affect memory, ovariectomized female rats were infused with either the LH-homologue human chorionic gonadotropin (hCG) or the LH receptor antagonist deglycosylated-hCG (dg-hCG). Infusion of hCG into either the lateral ventricle or the dorsal hippocampus caused significant memory impairments in ovariectomized estradiol-treated females. Consistent with this, infusion of the LH antagonist dg-hCG into the dorsal hippocampus caused an amelioration of memory deficits in ovariectomized females. Furthermore, the gonadotropin-releasing hormone antagonist Antide, failed to act in the hippocampus to affect memory. These findings demonstrate a significant role for LH action in the dorsal hippocampus in spatial memory dysfunction.en
dc.language.isoen_USen
dc.publisherElsevier for Academic Pressen
dc.identifier.doi10.1016/j.yhbeh.2016.11.007-
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0018506X16302124en
dc.subject.departmentNeuroscienceen_US
dc.titleLuteinizing hormone acts at the hippocampus to dampen spatial memoryen_US
dc.typeArticleen
dc.identifier.journalHormones and Behavioren
dc.subject.keywordLuteinizing hormoneen_US
dc.subject.keywordSpatial memoryen_US
dc.subject.keywordHippocampusen_US
dc.subject.keywordAlzheimer's diseaseen_US
dc.subject.keywordAgingen_US
dc.subject.keywordEstrogenen_US
dc.identifier.volume89en_US
dc.identifier.startpage55en_US
dc.rightsArchived with thanks to Hormones and Behavioren
All Items in The Five Colleges of Ohio Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.