Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability

Title:
Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability
Authors:
Paine, Tracie A.; Swedlow, Nathan; Swetschinski, Lucien
Abstract:
INTRODUCTION: Decreased sociability is a symptom of psychiatric conditions including autism-spectrum disorder and schizophrenia. Both of these conditions are associated with decreases in GABA function, particularly in the medial prefrontal cortex (PFC) and the basolateral amygdala (BLA); structures that are components of the social brain. Here, we determined if decreasing GABA transmission within either the PFC or the BLA decreases social behavior. METHODS: Rats were implanted with cannulae aimed at either the medial PFC or the BLA and then were tested on up to 4 behavioral tests following bilateral infusions of 0.5 mu l bicuculline methiodide (BMI, a GABA(A) receptor antagonist) at doses of 0, 25, or 50 ng/l. Rats were tested in the social interaction test, the social preference test, the sucrose preference test and for locomotor activity (BLA infusions only). RESULTS: Intra-BLA or PFC BMI infusions decreased the amount of time and the number of social interactions in the social interaction test. Further, in the social preference test, rats infused with 50 ng BMI no longer exhibited a preference to explore a social over a non-social stimulus. The change in sociability was not due to a change in reward processing or locomotor behavior. DISCUSSION: Decreasing GABA transmission in either the medial PFC or BLA decreased sociability. Thus, changes in GABA signaling observed in conditions such as autism or schizophrenia may mediate the social withdrawal characteristic of these conditions. Moreover, they suggest that social withdrawal may be treated by drugs that potentiate GABA transmission.
Citation:
Paine, Tracie A., Nathan Swedlow, and Lucien Swetschinski. 2017. "Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability." Behavioural Brain Research 317: 542-552.
Publisher:
Elsevier
DATE ISSUED:
2017-01
Department:
Neuroscience
Type:
Article
PUBLISHED VERSION:
10.1016/j.bbr.2016.10.012
PERMANENT LINK:
http://hdl.handle.net/11282/620297

Full metadata record

DC FieldValue Language
dc.contributor.authorPaine, Tracie A.en
dc.contributor.authorSwedlow, Nathanen
dc.contributor.authorSwetschinski, Lucienen
dc.date.accessioned2017-03-09T14:55:40Z-
dc.date.available2017-03-09T14:55:40Z-
dc.date.issued2017-01-
dc.identifier.citationPaine, Tracie A., Nathan Swedlow, and Lucien Swetschinski. 2017. "Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability." Behavioural Brain Research 317: 542-552.en
dc.identifier.issn0166-4328-
dc.identifier.urihttp://hdl.handle.net/11282/620297-
dc.description.abstractINTRODUCTION: Decreased sociability is a symptom of psychiatric conditions including autism-spectrum disorder and schizophrenia. Both of these conditions are associated with decreases in GABA function, particularly in the medial prefrontal cortex (PFC) and the basolateral amygdala (BLA); structures that are components of the social brain. Here, we determined if decreasing GABA transmission within either the PFC or the BLA decreases social behavior. METHODS: Rats were implanted with cannulae aimed at either the medial PFC or the BLA and then were tested on up to 4 behavioral tests following bilateral infusions of 0.5 mu l bicuculline methiodide (BMI, a GABA(A) receptor antagonist) at doses of 0, 25, or 50 ng/l. Rats were tested in the social interaction test, the social preference test, the sucrose preference test and for locomotor activity (BLA infusions only). RESULTS: Intra-BLA or PFC BMI infusions decreased the amount of time and the number of social interactions in the social interaction test. Further, in the social preference test, rats infused with 50 ng BMI no longer exhibited a preference to explore a social over a non-social stimulus. The change in sociability was not due to a change in reward processing or locomotor behavior. DISCUSSION: Decreasing GABA transmission in either the medial PFC or BLA decreased sociability. Thus, changes in GABA signaling observed in conditions such as autism or schizophrenia may mediate the social withdrawal characteristic of these conditions. Moreover, they suggest that social withdrawal may be treated by drugs that potentiate GABA transmission.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.identifier.doi10.1016/j.bbr.2016.10.012-
dc.subject.departmentNeuroscienceen_US
dc.titleDecreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociabilityen_US
dc.typeArticleen
dc.identifier.journalBehavioural Brain Researchen
dc.subject.keywordSociabilityen_US
dc.subject.keywordPrefrontal cortexen_US
dc.subject.keywordBasolateral amygdalaen_US
dc.subject.keywordGABA(A) receptoren_US
dc.subject.keywordSchizophreniaen_US
dc.subject.keywordAutismen_US
dc.identifier.volume317en_US
dc.identifier.startpage542en_US
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