Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory

Title:
Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory
Authors:
Borroni, Albert; Fichtenholtz, H.; Woodside, B. L.; Teyler, T. J.
Abstract:
This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 dperiod, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).
Citation:
Borroni, A.M., H. Fichtenholtz, B.L. Woodside, and T.J. Teyler. 2000. "Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory." Journal of Neuroscience 20(24): 9272-9276.
Publisher:
Journal of Neuroscience
DATE ISSUED:
2000-12-15
Department:
Neuroscience
Type:
Article
Additional Links:
http://www.jneurosci.org/content/20/24/9272
PERMANENT LINK:
http://hdl.handle.net/11282/620284

Full metadata record

DC FieldValue Language
dc.contributor.authorBorroni, Alberten
dc.contributor.authorFichtenholtz, H.en
dc.contributor.authorWoodside, B. L.en
dc.contributor.authorTeyler, T. J.en
dc.date.accessioned2017-01-12T19:25:17Z-
dc.date.available2017-01-12T19:25:17Z-
dc.date.issued2000-12-15-
dc.identifier.citationBorroni, A.M., H. Fichtenholtz, B.L. Woodside, and T.J. Teyler. 2000. "Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory." Journal of Neuroscience 20(24): 9272-9276.en
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/11282/620284-
dc.description.abstractThis experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 dperiod, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).en
dc.language.isoen_USen
dc.publisherJournal of Neuroscienceen
dc.relation.urlhttp://www.jneurosci.org/content/20/24/9272en
dc.subject.departmentNeuroscienceen_US
dc.titleRole of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memoryen_US
dc.typeArticleen
dc.identifier.journalJournal of Neuroscienceen
dc.subject.keywordLong-term potentiationen_US
dc.subject.keywordAntagonist MK-801en_US
dc.subject.keywordHippocampusen_US
dc.identifier.volume20en_US
dc.identifier.issue24en_US
dc.identifier.startpage9272en_US
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