Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery

Title:
Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery
Authors:
Levine, Dana J.; Runčevski, Tomče; Kapelewski, Matthew T.; Keitz, Benjamin K.; Oktawiec, Julia; Reed, Douglas A.; Mason, Jarad A.; Jiang, Henry Z. H.; Colwell, Kristen A.; Legendre, Christina M.; FitzGerald, Stephen; Long, Jeffrey R.
Abstract:
The drug olsalazine (H4olz) was employed as a ligand to synthesize a new series of mesoporous metal–organic frameworks that are expanded analogues of the well-known M2(dobdc) materials (dobdc4– = 2,5-dioxido-1,4-benzenedicarboxylate; M-MOF-74). The M2(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diameter. Variable temperature H2 adsorption isotherms revealed strong adsorption at the open metal sites, and in situ infrared spectroscopy experiments on Mg2(olz) and Ni2(olz) were used to determine site-specific H2 binding enthalpies. In addition to its capabilities for gas sorption, the highly biocompatible Mg2(olz) framework was also evaluated as a platform for the delivery of olsalazine and other encapsulated therapeutics. The Mg2(olz) material (86 wt % olsalazine) was shown to release the therapeutic linker through dissolution of the framework under simulated physiological conditions. Furthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds. Under simulated physiological conditions, Mg2(olz)(PEA)2 disassembled to release PEA from the pores and olsalazine from the framework itself, demonstrating that multiple therapeutic components can be delivered together at different rates. The low toxicity, high surface areas, and coordinatively unsaturated metal sites make these M2(olz) materials promising for a range of potential applications, including drug delivery in the treatment of gastrointestinal diseases.
Citation:
Levine, Dana J., Tomče Runčevski, Matthew T. Kapelewski, et al. 2016. "Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery." Journal of American Chemical Society 138(32): 10143-10150.
Publisher:
American Chemical Society
DATE ISSUED:
2016
Department:
Physics and Astronomy
Type:
Article
PUBLISHED VERSION:
10.1021/jacs.6b03523
PERMANENT LINK:
http://hdl.handle.net/11282/620176

Full metadata record

DC FieldValue Language
dc.contributor.authorLevine, Dana J.en
dc.contributor.authorRunčevski, Tomčeen
dc.contributor.authorKapelewski, Matthew T.en
dc.contributor.authorKeitz, Benjamin K.en
dc.contributor.authorOktawiec, Juliaen
dc.contributor.authorReed, Douglas A.en
dc.contributor.authorMason, Jarad A.en
dc.contributor.authorJiang, Henry Z. H.en
dc.contributor.authorColwell, Kristen A.en
dc.contributor.authorLegendre, Christina M.en
dc.contributor.authorFitzGerald, Stephenen
dc.contributor.authorLong, Jeffrey R.en
dc.date.accessioned2016-10-25T12:50:34Z-
dc.date.available2016-10-25T12:50:34Z-
dc.date.issued2016-
dc.identifier.citationLevine, Dana J., Tomče Runčevski, Matthew T. Kapelewski, et al. 2016. "Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery." Journal of American Chemical Society 138(32): 10143-10150.en
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/11282/620176-
dc.description.abstractThe drug olsalazine (H4olz) was employed as a ligand to synthesize a new series of mesoporous metal–organic frameworks that are expanded analogues of the well-known M2(dobdc) materials (dobdc4– = 2,5-dioxido-1,4-benzenedicarboxylate; M-MOF-74). The M2(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diameter. Variable temperature H2 adsorption isotherms revealed strong adsorption at the open metal sites, and in situ infrared spectroscopy experiments on Mg2(olz) and Ni2(olz) were used to determine site-specific H2 binding enthalpies. In addition to its capabilities for gas sorption, the highly biocompatible Mg2(olz) framework was also evaluated as a platform for the delivery of olsalazine and other encapsulated therapeutics. The Mg2(olz) material (86 wt % olsalazine) was shown to release the therapeutic linker through dissolution of the framework under simulated physiological conditions. Furthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds. Under simulated physiological conditions, Mg2(olz)(PEA)2 disassembled to release PEA from the pores and olsalazine from the framework itself, demonstrating that multiple therapeutic components can be delivered together at different rates. The low toxicity, high surface areas, and coordinatively unsaturated metal sites make these M2(olz) materials promising for a range of potential applications, including drug delivery in the treatment of gastrointestinal diseases.en
dc.language.isoen_USen
dc.publisherAmerican Chemical Societyen
dc.identifier.doi10.1021/jacs.6b03523-
dc.subject.departmentPhysics and Astronomyen_US
dc.titleOlsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Deliveryen_US
dc.typeArticleen
dc.identifier.journalJournal of the American Chemical Societyen
dc.identifier.volume138en_US
dc.identifier.issue32en_US
dc.identifier.startpage10143en_US
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