Model of the TIR1 Pathway for Auxin-Mediated Gene Expression

Title:
Model of the TIR1 Pathway for Auxin-Mediated Gene Expression
Authors:
Laskowski, Marta ( 0000-0002-8875-7627 )
Abstract:
Auxin mediates numerous plant responses, some of which have been shown to require transcriptional regulation. One auxin response pathway, which depends on the relief of transcriptional repression, is mediated by TIR1 (transport inhibitor response protein 1). TIR1 is an auxin receptor and also a subunit of an SCF-type ubiquitin ligase. In the presence of a low concentration of auxin in the nucleus, members of the Aux/IAA family of transcriptional repressors bind to ARF proteins and inhibit the transcription of specific auxin response genes. Increased nuclear concentrations of auxin promote auxin binding to TIR1, causing the Aux/IAA proteins to associate with TIR1 and leading to their degradation by a proteasome-mediated pathway. This decreases the concentration of Aux/IAA proteins in the nucleus and thereby enables the expression of certain auxin response genes.
Citation:
Laskowski, Marta. 2006. "Model of the TIR1 Pathway for Auxin-Mediated Gene Expression." Science Signaling 2006(322): tr1.
Publisher:
American Association for the Advancement of Science
DATE ISSUED:
2006-02-07
Department:
Biology
Type:
Article
PUBLISHED VERSION:
10.1126/stke.3222006tr1
Additional Links:
http://stke.sciencemag.org/cgi/doi/10.1126/stke.3222006tr1
PERMANENT LINK:
http://hdl.handle.net/11282/607256

Full metadata record

DC FieldValue Language
dc.contributor.authorLaskowski, Martaen
dc.date.accessioned2016-04-27T19:05:37Zen
dc.date.available2016-04-27T19:05:37Zen
dc.date.issued2006-02-07en
dc.identifier.citationLaskowski, Marta. 2006. "Model of the TIR1 Pathway for Auxin-Mediated Gene Expression." Science Signaling 2006(322): tr1.en
dc.identifier.issn1945-0877en
dc.identifier.urihttp://hdl.handle.net/11282/607256en
dc.description.abstractAuxin mediates numerous plant responses, some of which have been shown to require transcriptional regulation. One auxin response pathway, which depends on the relief of transcriptional repression, is mediated by TIR1 (transport inhibitor response protein 1). TIR1 is an auxin receptor and also a subunit of an SCF-type ubiquitin ligase. In the presence of a low concentration of auxin in the nucleus, members of the Aux/IAA family of transcriptional repressors bind to ARF proteins and inhibit the transcription of specific auxin response genes. Increased nuclear concentrations of auxin promote auxin binding to TIR1, causing the Aux/IAA proteins to associate with TIR1 and leading to their degradation by a proteasome-mediated pathway. This decreases the concentration of Aux/IAA proteins in the nucleus and thereby enables the expression of certain auxin response genes.en
dc.publisherAmerican Association for the Advancement of Scienceen
dc.identifier.doi10.1126/stke.3222006tr1en
dc.relation.urlhttp://stke.sciencemag.org/cgi/doi/10.1126/stke.3222006tr1en
dc.subject.departmentBiologyen_US
dc.titleModel of the TIR1 Pathway for Auxin-Mediated Gene Expressionen
dc.typeArticleen
dc.identifier.journalScience Signalingen
dc.identifier.volume206en_US
dc.identifier.issue322en_US
dc.rightsArchived with thanks to Science Signalingen
All Items in The Five Colleges of Ohio Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.