Title:
Early pregnancy factor in marsupials
Authors:
Cruz, Yolanda P.; Morton, H.; Cavanagh, A. C.; Selwood, Lynne; Wilson, Siobhan D.; Sasaki, Mark M.
Abstract:
Maternal recognition of pregnancy in marsupials occurs in more subtle ways than it does in eutherians. For instance, unlike in eutherians, the plasma progesterone profiles of pregnant and non-pregnant animals are similar during the luteal phase. It is typically during the brief luteal phase that both gestation and parturition occur in marsupials. Yet histological and physiological changes have been documented between gravid and non-gravid uteri in certain monovular marsupials and between pregnant and non-pregnant animals in polyovular marsupials. Early pregnancy factor (EPF), a 10.8-kDa serum protein known to be homologous to chaperonin 10, is associated with maternal immunosuppression, embryonic development and pregnancy in eutherian mammals. It has been reported in two Australian marsupials: the dasyurid Sminthopsis macroura and the phalangerid Trichosurus vulpecula. This paper documents its occurrence in the New World didelphid Monodelphis domestica. EPF is detectable by rosette inhibition assay in the peripheral circulation of pregnant but not of non-pregnant or pseudopregnant animals. Our work focuses on the embryo–maternal signalling role of EPF during pregnancy. Because progesterone-driven changes are similar in pregnant and non-pregnant marsupials, these animals are an excellent laboratory model in which to investigate the role of EPF in orchestrating the physiological changes necessary to sustain pregnancy.
Citation:
Cruz, Y.P., H. Morton, A.C. Cavanagh, et al. 2006. "Early pregnancy factor in marsupials." Australian Journal of Zoology 54(3): 211-215.
Publisher:
CSIRO Publishing
DATE ISSUED:
2006
Department:
Biology
Type:
Article
PUBLISHED VERSION:
10.1071/ZO05050
Additional Links:
http://www.publish.csiro.au/?paper=ZO05050
PERMANENT LINK:
http://hdl.handle.net/11282/600495

Full metadata record

DC FieldValue Language
dc.contributor.authorCruz, Yolanda P.en
dc.contributor.authorMorton, H.en
dc.contributor.authorCavanagh, A. C.en
dc.contributor.authorSelwood, Lynneen
dc.contributor.authorWilson, Siobhan D.en
dc.contributor.authorSasaki, Mark M.en
dc.date.accessioned2016-03-02T14:34:45Zen
dc.date.available2016-03-02T14:34:45Zen
dc.date.issued2006en
dc.identifier.citationCruz, Y.P., H. Morton, A.C. Cavanagh, et al. 2006. "Early pregnancy factor in marsupials." Australian Journal of Zoology 54(3): 211-215.en
dc.identifier.issn0004-959Xen
dc.identifier.urihttp://hdl.handle.net/11282/600495en
dc.description.abstractMaternal recognition of pregnancy in marsupials occurs in more subtle ways than it does in eutherians. For instance, unlike in eutherians, the plasma progesterone profiles of pregnant and non-pregnant animals are similar during the luteal phase. It is typically during the brief luteal phase that both gestation and parturition occur in marsupials. Yet histological and physiological changes have been documented between gravid and non-gravid uteri in certain monovular marsupials and between pregnant and non-pregnant animals in polyovular marsupials. Early pregnancy factor (EPF), a 10.8-kDa serum protein known to be homologous to chaperonin 10, is associated with maternal immunosuppression, embryonic development and pregnancy in eutherian mammals. It has been reported in two Australian marsupials: the dasyurid Sminthopsis macroura and the phalangerid Trichosurus vulpecula. This paper documents its occurrence in the New World didelphid Monodelphis domestica. EPF is detectable by rosette inhibition assay in the peripheral circulation of pregnant but not of non-pregnant or pseudopregnant animals. Our work focuses on the embryo–maternal signalling role of EPF during pregnancy. Because progesterone-driven changes are similar in pregnant and non-pregnant marsupials, these animals are an excellent laboratory model in which to investigate the role of EPF in orchestrating the physiological changes necessary to sustain pregnancy.en
dc.language.isoen_USen
dc.publisherCSIRO Publishingen
dc.identifier.doi10.1071/ZO05050en
dc.relation.urlhttp://www.publish.csiro.au/?paper=ZO05050en
dc.subject.departmentBiologyen_US
dc.titleEarly pregnancy factor in marsupialsen_US
dc.typeArticleen
dc.identifier.journalAustralian Journal of Zoologyen
dc.identifier.volume54en_US
dc.identifier.issue3en_US
dc.identifier.startpage211en_US
dc.rightsArchived with thanks to Australian Journal of Zoologyen
All Items in The Five Colleges of Ohio Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.