Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

Title:
Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features
Authors:
Kwakye, Gunnar; Paoliello, Monica; Mukhopadhyay, Somshuvra; Bowman, Aaron B.; Aschner, Michael
Abstract:
Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson's disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson's disease (PD).
Citation:
Kwakye, G.F., M.M.B. Paoliello, S. Mukhopadhyay, et al. 2015. "Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features." International Journal of Environmental Research and Public Health 12(7): 7519-7540.
Publisher:
MDPI
DATE ISSUED:
2015-07-06
Department:
Neuroscience
Type:
Article
PUBLISHED VERSION:
10.3390/ijerph120707519
Additional Links:
http://www.mdpi.com/1660-4601/12/7/7519/
Notes:
The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn.
PERMANENT LINK:
http://hdl.handle.net/11282/594364

Full metadata record

DC FieldValue Language
dc.contributor.authorKwakye, Gunnaren
dc.contributor.authorPaoliello, Monicaen
dc.contributor.authorMukhopadhyay, Somshuvraen
dc.contributor.authorBowman, Aaron B.en
dc.contributor.authorAschner, Michaelen
dc.date.accessioned2016-01-19T16:37:37Zen
dc.date.available2016-01-19T16:37:37Zen
dc.date.issued2015-07-06en
dc.identifier.citationKwakye, G.F., M.M.B. Paoliello, S. Mukhopadhyay, et al. 2015. "Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features." International Journal of Environmental Research and Public Health 12(7): 7519-7540.en
dc.identifier.issn1660-4601en
dc.identifier.urihttp://hdl.handle.net/11282/594364en
dc.description.abstractManganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson's disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson's disease (PD).en
dc.language.isoen_USen
dc.publisherMDPIen
dc.identifier.doi10.3390/ijerph120707519en
dc.relation.urlhttp://www.mdpi.com/1660-4601/12/7/7519/en
dc.subject.departmentNeuroscienceen_US
dc.titleManganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Featuresen_US
dc.typeArticleen
dc.description.notesThe present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn.en_US
dc.identifier.journalInternational Journal of Environmental Research and Public Healthen
dc.subject.keywordManganese-induced parkinsonismen_US
dc.subject.keywordManganese neurotoxicityen_US
dc.subject.keywordParkinson's disease (PD)en_US
dc.subject.keywordManganismen_US
dc.subject.keywordNeurodegenerative diseasesen_US
dc.identifier.volume12en_US
dc.identifier.issue7en_US
dc.identifier.startpage7519en_US
dc.rightsArchived with thanks to International Journal of Environmental Research and Public Healthen
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