Leucocyte response to Eastern Equine Encephalomyelitis Encephalitis virus in a wild passerine bird

Title:
Leucocyte response to Eastern Equine Encephalomyelitis Encephalitis virus in a wild passerine bird
Authors:
Owen, Jennifer C.; Cornelius, E. A.; Arsnoe, D. A.; Garvin, Mary C.
Abstract:
Leukocyte counts are frequently used to assess the immunologic status of animals; however, few studies have directly looked at the predictive value of leukocyte counts and an animal's ability to respond to an infection with a pathogen. Understanding how an animal's leukocyte profile is altered by an active infection can assist with interpretation of leukocyte profiles in animals for which infection status is not known. In this study we examine the leukocyte counts of gray catbirds (Dumetella carolinensis) infected with eastern equine encephalomyelitis virus (EEEV). Blood smears were collected from infected catbirds on -4, 2, 5, and 14 days postinoculation (dpi) with EEEV, and from a corresponding uninfected control group, to monitor leukocyte counts. Although we found that preinfection leukocyte counts were not a reliable predictive of a catbird's viremia, we did find that infected catbirds exhibited significant hematologic changes in response to EEEV infection. We observed a significant drop in all subpopulations of leukocytes (i.e., lymphocytes, monocytes, and granulocytes) following infection. Lymphocytes and granulocytes still had not recovered to preinfection levels at 14 dpi. Uninfected catbirds also exhibited statistically significant changes in leukocyte counts, but this was due to a slight increase at 14 dpi and was not considered biologically relevant. Studies such as this can provide important information for field ecoimmunologists that use leukocyte counts to assess immunocompetence in free-living animals.
Citation:
Owen, J.C., E.A. Cornelius, D.A. Arsnoe, and M.C. Garvin. 2013. “Leucocyte response to Eastern Equine Encephalomyelitis Encephalitis virus in a wild passerine bird." Avian Diseases 57(4): 744-749.
Publisher:
American Association of Avian Pathologists, Inc.
DATE ISSUED:
2013
Department:
Biology
Type:
Article
PUBLISHED VERSION:
10.1637/10574-051513-Reg.1
PERMANENT LINK:
http://hdl.handle.net/11282/332419

Full metadata record

DC FieldValue Language
dc.contributor.authorOwen, Jennifer C.en
dc.contributor.authorCornelius, E. A.en
dc.contributor.authorArsnoe, D. A.en
dc.contributor.authorGarvin, Mary C.en
dc.date.accessioned2014-10-09T12:03:24Zen
dc.date.available2014-10-09T12:03:24Zen
dc.date.issued2013en
dc.identifier.citationOwen, J.C., E.A. Cornelius, D.A. Arsnoe, and M.C. Garvin. 2013. “Leucocyte response to Eastern Equine Encephalomyelitis Encephalitis virus in a wild passerine bird." Avian Diseases 57(4): 744-749.en
dc.identifier.issn0005-2086en
dc.identifier.urihttp://hdl.handle.net/11282/332419en
dc.description.abstractLeukocyte counts are frequently used to assess the immunologic status of animals; however, few studies have directly looked at the predictive value of leukocyte counts and an animal's ability to respond to an infection with a pathogen. Understanding how an animal's leukocyte profile is altered by an active infection can assist with interpretation of leukocyte profiles in animals for which infection status is not known. In this study we examine the leukocyte counts of gray catbirds (Dumetella carolinensis) infected with eastern equine encephalomyelitis virus (EEEV). Blood smears were collected from infected catbirds on -4, 2, 5, and 14 days postinoculation (dpi) with EEEV, and from a corresponding uninfected control group, to monitor leukocyte counts. Although we found that preinfection leukocyte counts were not a reliable predictive of a catbird's viremia, we did find that infected catbirds exhibited significant hematologic changes in response to EEEV infection. We observed a significant drop in all subpopulations of leukocytes (i.e., lymphocytes, monocytes, and granulocytes) following infection. Lymphocytes and granulocytes still had not recovered to preinfection levels at 14 dpi. Uninfected catbirds also exhibited statistically significant changes in leukocyte counts, but this was due to a slight increase at 14 dpi and was not considered biologically relevant. Studies such as this can provide important information for field ecoimmunologists that use leukocyte counts to assess immunocompetence in free-living animals.en
dc.language.isoen_USen
dc.publisherAmerican Association of Avian Pathologists, Inc.en
dc.identifier.doi10.1637/10574-051513-Reg.1en_US
dc.subject.departmentBiologyen
dc.titleLeucocyte response to Eastern Equine Encephalomyelitis Encephalitis virus in a wild passerine birden
dc.typeArticleen
dc.identifier.journalAvian Diseasesen
dc.subject.keywordEastern equine encephalomyelitis virusen_US
dc.subject.keywordLeukocyte profilesen_US
dc.subject.keywordInfectionen_US
dc.subject.keywordTiteren_US
dc.subject.keywordPasserineen_US
dc.identifier.volume57en
dc.identifier.issue4en
dc.identifier.startpage744en
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