Does Progesterone Have A Role In Embryo-maternal Communication In Monodelphis Domestica?

Title:
Does Progesterone Have A Role In Embryo-maternal Communication In Monodelphis Domestica?
Authors:
Johnson, Joanna M.
Abstract:
Unlike eutherian mammals, marsupials generally exhibit no significant rise in serum during pregnancy. This observation has led to the conventional view that maternal recognition of pregnancy does not occur among marsupials. However, recent radioimmunoassay work with Monodelphis domestica reveals a slight increase in serum progesterone during the early stages of the 14-day pregnancy in this marsupial, peaking at day 3 and day 9. This elevation is consistent with specific nuclear staining of uterine-gland cells for progesterone receptor (PR), which occurs on days 3 to 9 of gestation. In addition, the PR-positive nuclei of uterine-gland cells during this period are situated near the basal lamina instead of their usual position at the center of each such cell. Consistent staining pattern of progesterone receptors in corpora lutea and ovarian follicles suggest minimal interaction between progesterone and involvement of the ovaries during gestation. However, the slight rise in serum progesterone, in combination with a significant increase in PR expression in the uterine-gland cells, suggests that progesterone signaling may play a heretofore under-appreciated role in marsupial pregnancy.
Citation:
Johnson, Joanna M. 2011. "Does Progesterone Have A Role In Embryo-maternal Communication In Monodelphis Domestica?." Developmental Biology 356(1): 249.
Publisher:
Elsevier
DATE ISSUED:
2011-08
Department:
Biology
Type:
article
PUBLISHED VERSION:
10.1016/j.ydbio.2011.05.553
PERMANENT LINK:
http://hdl.handle.net/11282/310106

Full metadata record

DC FieldValue Language
dc.contributor.authorJohnson, Joanna M.en_US
dc.date.accessioned2013-12-23T16:25:30Z-
dc.date.available2013-12-23T16:25:30Z-
dc.date.issued2011-08en
dc.identifier.citationJohnson, Joanna M. 2011. "Does Progesterone Have A Role In Embryo-maternal Communication In Monodelphis Domestica?." Developmental Biology 356(1): 249.en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/11282/310106-
dc.description.abstractUnlike eutherian mammals, marsupials generally exhibit no significant rise in serum during pregnancy. This observation has led to the conventional view that maternal recognition of pregnancy does not occur among marsupials. However, recent radioimmunoassay work with Monodelphis domestica reveals a slight increase in serum progesterone during the early stages of the 14-day pregnancy in this marsupial, peaking at day 3 and day 9. This elevation is consistent with specific nuclear staining of uterine-gland cells for progesterone receptor (PR), which occurs on days 3 to 9 of gestation. In addition, the PR-positive nuclei of uterine-gland cells during this period are situated near the basal lamina instead of their usual position at the center of each such cell. Consistent staining pattern of progesterone receptors in corpora lutea and ovarian follicles suggest minimal interaction between progesterone and involvement of the ovaries during gestation. However, the slight rise in serum progesterone, in combination with a significant increase in PR expression in the uterine-gland cells, suggests that progesterone signaling may play a heretofore under-appreciated role in marsupial pregnancy.en_US
dc.publisherElsevieren_US
dc.identifier.doi10.1016/j.ydbio.2011.05.553-
dc.subject.departmentBiologyen_US
dc.titleDoes Progesterone Have A Role In Embryo-maternal Communication In Monodelphis Domestica?en_US
dc.typearticleen_US
dc.identifier.journalDevelopmental Biologyen_US
dc.identifier.volume356en_US
dc.identifier.issue1en_US
dc.identifier.startpage249en_US
All Items in The Five Colleges of Ohio Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.