Estradiol Alleviates Cognitive Deficits Induced By Sub-chronic Phencyclidine Administration In Ovariectomized Rats

Title:
Estradiol Alleviates Cognitive Deficits Induced By Sub-chronic Phencyclidine Administration In Ovariectomized Rats
Authors:
Roseman, Alexander S.; Thornton, Janice E.
Abstract:
Clinical studies have suggested that estrogens may affect the symptoms of schizophrenia. The novel object recognition task (NORT) in female rats treated with sub-chronic phencyclidine (PCP) was used as an animal model of the cognitive deficits in schizophrenia. The current studies investigated whether chronic estradiol (E) could alleviate sub-chronic PCP-induced cognitive deficits in the NORT. Adult Sprague-Dawley rats were ovariectomized (ovx) and treated with either sub-chronic PCP (2 mg/kg bidaily i.p. for seven days), or with 0.9% saline and their object recognition memory was tested with the NORT using an acquisition trial, 1 min inter-trial interval, and retention trial. Sub-chronic PCP administration did not reliably affect behavior in the acquisition trial but significantly impaired object recognition in the retention trial for 1-2 and 27-29 weeks. Ovx females spent significantly (p<0.05) more time exploring the novel compared to the familiar object, whereas PCP-treated ovx females did not. This effect of PCP was attenuated by long-lasting E capsules implanted prior to PCP treatment. PCP-treated females implanted with E again spent significantly more time exploring the novel compared to the familiar object (p<0.01). When ovx rats were treated with sub-chronic PCP and a long-lasting E capsule was implanted either before or after PCP treatment, estradiol alleviated the PCP-induced deficits when administered in either regimen (p=0.01 and p=0.047 respectively). These data suggest that further exploration of estradiol as a possible therapeutic compound to treat the cognitive deficits of schizophrenia is warranted.
Citation:
Roseman, A. S., and J. E. Thornton. 2009. "Estradiol Alleviates Cognitive Deficits Induced By Sub-chronic Phencyclidine Administration In Ovariectomized Rats." Society For Neuroscience Abstract Viewer And Itinerary Planner 39.
Publisher:
Society for Neuroscience
DATE ISSUED:
2009
Department:
Neuroscience
Type:
article
PERMANENT LINK:
http://hdl.handle.net/11282/310057

Full metadata record

DC FieldValue Language
dc.contributor.authorRoseman, Alexander S.en_US
dc.contributor.authorThornton, Janice E.en_US
dc.date.accessioned2013-12-23T16:24:19Zen
dc.date.available2013-12-23T16:24:19Zen
dc.date.issued2009en
dc.identifier.citationRoseman, A. S., and J. E. Thornton. 2009. "Estradiol Alleviates Cognitive Deficits Induced By Sub-chronic Phencyclidine Administration In Ovariectomized Rats." Society For Neuroscience Abstract Viewer And Itinerary Planner 39.en_US
dc.identifier.issn0190-5295en_US
dc.identifier.urihttp://hdl.handle.net/11282/310057en
dc.description.abstractClinical studies have suggested that estrogens may affect the symptoms of schizophrenia. The novel object recognition task (NORT) in female rats treated with sub-chronic phencyclidine (PCP) was used as an animal model of the cognitive deficits in schizophrenia. The current studies investigated whether chronic estradiol (E) could alleviate sub-chronic PCP-induced cognitive deficits in the NORT. Adult Sprague-Dawley rats were ovariectomized (ovx) and treated with either sub-chronic PCP (2 mg/kg bidaily i.p. for seven days), or with 0.9% saline and their object recognition memory was tested with the NORT using an acquisition trial, 1 min inter-trial interval, and retention trial. Sub-chronic PCP administration did not reliably affect behavior in the acquisition trial but significantly impaired object recognition in the retention trial for 1-2 and 27-29 weeks. Ovx females spent significantly (p<0.05) more time exploring the novel compared to the familiar object, whereas PCP-treated ovx females did not. This effect of PCP was attenuated by long-lasting E capsules implanted prior to PCP treatment. PCP-treated females implanted with E again spent significantly more time exploring the novel compared to the familiar object (p<0.01). When ovx rats were treated with sub-chronic PCP and a long-lasting E capsule was implanted either before or after PCP treatment, estradiol alleviated the PCP-induced deficits when administered in either regimen (p=0.01 and p=0.047 respectively). These data suggest that further exploration of estradiol as a possible therapeutic compound to treat the cognitive deficits of schizophrenia is warranted.en_US
dc.publisherSociety for Neuroscienceen_US
dc.subject.departmentNeuroscienceen_US
dc.titleEstradiol Alleviates Cognitive Deficits Induced By Sub-chronic Phencyclidine Administration In Ovariectomized Ratsen_US
dc.typearticleen_US
dc.identifier.journalSociety For Neuroscience Abstract Viewer And Itinerary Planneren_US
dc.identifier.volume39en_US
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