Pregnancy-related Changes In Progesterone Receptor Expression In The Uterine Glands Of Monodelphis Domestica

Title:
Pregnancy-related Changes In Progesterone Receptor Expression In The Uterine Glands Of Monodelphis Domestica
Authors:
Johnson, Joanna M.; Lydon, John; Harder, John D.; Cruz, Yolanda P.
Abstract:
Unlike eutherian mammals, marsupials generally exhibit no significant rise in serum progesterone during pregnancy. This observation has led to the conventional view that maternal recognition of pregnancy does not occur among marsupials. However, recent radioimmunoassay work with Monodelphis domestica reveals a slight increase in serum progesterone during the early stages of the 14-day pregnancy in this marsupial, peaking at day 3. This elevation is consistent with specific nuclear staining of uterine-gland cells for progesterone receptor (PR), which occurs on days 3 to 8 of gestation. In addition, the PR-positive nuclei of uterine-gland cells during this period are situated near the basal lamina instead of their usual position at the center of each such cell. This in turn suggests that the nuclei are well positioned to respond to progesterone arriving at the gland via the interstitial fluid in direct contact with the basal laminae of uterine gland cells. The slight rise in serum progesterone, in combination with a significant increase in PR expression in the uterine-gland cells, may indicate that progesterone signaling may play a heretofore under-appreciated role in marsupial pregnancy.
Citation:
Johnson, Joanna M., John Lydon, John D. Harder, and Yolanda P. Cruz. 2010. "Pregnancy-related Changes In Progesterone Receptor Expression In The Uterine Glands Of Monodelphis Domestica." Developmental Biology 344(1): 214.
Publisher:
Academic Press/Elsevier Science
DATE ISSUED:
2010-08
Department:
Biology
Type:
article
PUBLISHED VERSION:
10.1016/j.ydbio.2010.05.255
PERMANENT LINK:
http://hdl.handle.net/11282/309972

Full metadata record

DC FieldValue Language
dc.contributor.authorJohnson, Joanna M.en_US
dc.contributor.authorLydon, Johnen_US
dc.contributor.authorHarder, John D.en_US
dc.contributor.authorCruz, Yolanda P.en_US
dc.date.accessioned2013-12-23T16:22:18Zen
dc.date.available2013-12-23T16:22:18Zen
dc.date.issued2010-08en
dc.identifier.citationJohnson, Joanna M., John Lydon, John D. Harder, and Yolanda P. Cruz. 2010. "Pregnancy-related Changes In Progesterone Receptor Expression In The Uterine Glands Of Monodelphis Domestica." Developmental Biology 344(1): 214.en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/11282/309972en
dc.description.abstractUnlike eutherian mammals, marsupials generally exhibit no significant rise in serum progesterone during pregnancy. This observation has led to the conventional view that maternal recognition of pregnancy does not occur among marsupials. However, recent radioimmunoassay work with Monodelphis domestica reveals a slight increase in serum progesterone during the early stages of the 14-day pregnancy in this marsupial, peaking at day 3. This elevation is consistent with specific nuclear staining of uterine-gland cells for progesterone receptor (PR), which occurs on days 3 to 8 of gestation. In addition, the PR-positive nuclei of uterine-gland cells during this period are situated near the basal lamina instead of their usual position at the center of each such cell. This in turn suggests that the nuclei are well positioned to respond to progesterone arriving at the gland via the interstitial fluid in direct contact with the basal laminae of uterine gland cells. The slight rise in serum progesterone, in combination with a significant increase in PR expression in the uterine-gland cells, may indicate that progesterone signaling may play a heretofore under-appreciated role in marsupial pregnancy.en_US
dc.language.isoen_USen_US
dc.publisherAcademic Press/Elsevier Scienceen_US
dc.identifier.doi10.1016/j.ydbio.2010.05.255en
dc.subject.departmentBiologyen_US
dc.titlePregnancy-related Changes In Progesterone Receptor Expression In The Uterine Glands Of Monodelphis Domesticaen_US
dc.typearticleen_US
dc.identifier.journalDevelopmental Biologyen_US
dc.subject.keywordDevelopmental biologyen_US
dc.identifier.volume344en_US
dc.identifier.issue1en_US
dc.identifier.startpage214en_US
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