Test Of Recrudescence Hypothesis For Overwintering Of West Nile Virus In Gray Catbirds

Title:
Test Of Recrudescence Hypothesis For Overwintering Of West Nile Virus In Gray Catbirds
Authors:
Owen, Jennifer C.; Moore, Frank R.; Williams, Amanda J.; Ward, M. P.; Beveroth, T. A.; Miller, Elizabeth A.; Wilson, L. C.; Morley, V. J.; Abbey-Lee, R. N.; Veeneman, B. A.; DeRussy, B. M.; McWhorter, M. S.; Garvin, Mary C.
Abstract:
West Nile virus is a pathogen of concern for both human and wildlife health. Although many aspects of the ecology of West Nile virus are well understood, the mechanisms by which this and similar mosquito-borne viruses overwinter and become reinitiated each spring in temperate regions is not known. A thorough understanding of this mechanism is crucial to risk assessment and development of control strategies. One of the hypotheses to explain the mechanism by which this virus persists from year to year is the spring recrudescence of latent virus in avian reservoir hosts. Stress-related immunosuppression is implicated in the recrudescence of latent viruses in birds. We tested the spring recrudescence hypothesis in a controlled laboratory experiment using hatching-year gray catbirds (Dumatella carolinensis) captured in northern Ohio (July-August 2006). Catbirds (n = 60) were experimentally infected (September 2006) and later examined for the effects of immunosuppression through exogenous hormones and artificially induced migratory disposition. We found no effect of either testosterone or migratory behavior on infection status in any of the treatment birds. Moreover, we detected no viral RNA in the kidney, spleen, brain, or liver upon necropsy at 24 wk postinfection.
Citation:
Owen, J. C., F. R. Moore, A. J. Williams, M. P. Ward, et al. 2010. "Test Of Recrudescence Hypothesis For Overwintering Of West Nile Virus In Gray Catbirds." Journal Of Medical Entomology 47(3): 451-457.
Publisher:
Entomological Society of America
DATE ISSUED:
2010-05
Department:
Biology
Type:
article
PUBLISHED VERSION:
10.1093/jmedent/47.3.451
PERMANENT LINK:
http://hdl.handle.net/11282/309916

Full metadata record

DC FieldValue Language
dc.contributor.authorOwen, Jennifer C.en_US
dc.contributor.authorMoore, Frank R.en_US
dc.contributor.authorWilliams, Amanda J.en_US
dc.contributor.authorWard, M. P.en_US
dc.contributor.authorBeveroth, T. A.en_US
dc.contributor.authorMiller, Elizabeth A.en_US
dc.contributor.authorWilson, L. C.en_US
dc.contributor.authorMorley, V. J.en_US
dc.contributor.authorAbbey-Lee, R. N.en_US
dc.contributor.authorVeeneman, B. A.en_US
dc.contributor.authorDeRussy, B. M.en_US
dc.contributor.authorMcWhorter, M. S.en_US
dc.contributor.authorGarvin, Mary C.en_US
dc.date.accessioned2013-12-23T16:20:59Zen
dc.date.available2013-12-23T16:20:59Zen
dc.date.issued2010-05en
dc.identifier.citationOwen, J. C., F. R. Moore, A. J. Williams, M. P. Ward, et al. 2010. "Test Of Recrudescence Hypothesis For Overwintering Of West Nile Virus In Gray Catbirds." Journal Of Medical Entomology 47(3): 451-457.en_US
dc.identifier.issn0022-2585en_US
dc.identifier.urihttp://hdl.handle.net/11282/309916en
dc.description.abstractWest Nile virus is a pathogen of concern for both human and wildlife health. Although many aspects of the ecology of West Nile virus are well understood, the mechanisms by which this and similar mosquito-borne viruses overwinter and become reinitiated each spring in temperate regions is not known. A thorough understanding of this mechanism is crucial to risk assessment and development of control strategies. One of the hypotheses to explain the mechanism by which this virus persists from year to year is the spring recrudescence of latent virus in avian reservoir hosts. Stress-related immunosuppression is implicated in the recrudescence of latent viruses in birds. We tested the spring recrudescence hypothesis in a controlled laboratory experiment using hatching-year gray catbirds (Dumatella carolinensis) captured in northern Ohio (July-August 2006). Catbirds (n = 60) were experimentally infected (September 2006) and later examined for the effects of immunosuppression through exogenous hormones and artificially induced migratory disposition. We found no effect of either testosterone or migratory behavior on infection status in any of the treatment birds. Moreover, we detected no viral RNA in the kidney, spleen, brain, or liver upon necropsy at 24 wk postinfection.en_US
dc.language.isoen_USen_US
dc.publisherEntomological Society of Americaen_US
dc.identifier.doi10.1093/jmedent/47.3.451en
dc.subject.departmentBiologyen_US
dc.titleTest Of Recrudescence Hypothesis For Overwintering Of West Nile Virus In Gray Catbirdsen_US
dc.typearticleen_US
dc.identifier.journalJournal Of Medical Entomologyen_US
dc.subject.keywordWest Nile virusen_US
dc.subject.keywordOverwinteringen_US
dc.subject.keywordDumetella carolinensisen_US
dc.subject.keywordTestosteroneen_US
dc.subject.keywordMigrationen_US
dc.identifier.volume47en_US
dc.identifier.issue3en_US
dc.identifier.startpage451en_US
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