Methods for providing therapeutic agents to treat damaged spiral ganglion neurons

Title:
Methods for providing therapeutic agents to treat damaged spiral ganglion neurons
Authors:
Bianchi, Lynne M.; Raz, Y.
Abstract:
Sensorineural hearing loss, characterized by damage to sensory hair cells and / or associated nerve fibers is a leading cause of hearing disorders throughout the world. To date, treatment options are limited and there is no cure for damaged inner ear cells. Because the inner ear is a tiny organ housed in bone deep within the skull, access to the inner ear is limited, making delivery of therapeutic agents difficult. In recent years scientists have investigated a number of growth factors that have the potential to regulate survival or recovery of auditory neurons. Coinciding with the focus on molecules that may restore function are efforts to develop novel delivery methods. Researchers have been investigating the use of mini osmotic pumps, viral vectors and stem cells as a means of providing direct application of growth factors to the inner ear. This review summarizes recent findings regarding the molecules that may be useful for restoring damaged spiral ganglion neurons, as well as the advantages and disadvantages of various delivery systems.
Citation:
Bianchi, L.M., and Y. Raz. 2004. "Methods for providing therapeutic agents to treat damaged spiral ganglion neurons." Current Drug Targets - CNS & Neurological Disorders 3(3): 195-199.
Publisher:
Bentham Science Publishers
DATE ISSUED:
2004-06
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.2174/1568007043337454
PERMANENT LINK:
http://hdl.handle.net/11282/309748

Full metadata record

DC FieldValue Language
dc.contributor.authorBianchi, Lynne M.en_US
dc.contributor.authorRaz, Y.en_US
dc.date.accessioned2013-12-23T16:17:00Zen
dc.date.available2013-12-23T16:17:00Zen
dc.date.issued2004-06en
dc.identifier.citationBianchi, L.M., and Y. Raz. 2004. "Methods for providing therapeutic agents to treat damaged spiral ganglion neurons." Current Drug Targets - CNS & Neurological Disorders 3(3): 195-199.en_US
dc.identifier.issn1568-007Xen_US
dc.identifier.urihttp://hdl.handle.net/11282/309748en
dc.description.abstractSensorineural hearing loss, characterized by damage to sensory hair cells and / or associated nerve fibers is a leading cause of hearing disorders throughout the world. To date, treatment options are limited and there is no cure for damaged inner ear cells. Because the inner ear is a tiny organ housed in bone deep within the skull, access to the inner ear is limited, making delivery of therapeutic agents difficult. In recent years scientists have investigated a number of growth factors that have the potential to regulate survival or recovery of auditory neurons. Coinciding with the focus on molecules that may restore function are efforts to develop novel delivery methods. Researchers have been investigating the use of mini osmotic pumps, viral vectors and stem cells as a means of providing direct application of growth factors to the inner ear. This review summarizes recent findings regarding the molecules that may be useful for restoring damaged spiral ganglion neurons, as well as the advantages and disadvantages of various delivery systems.en_US
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.identifier.doi10.2174/1568007043337454en
dc.subject.departmentNeuroscienceen_US
dc.titleMethods for providing therapeutic agents to treat damaged spiral ganglion neuronsen_US
dc.typearticleen_US
dc.identifier.journalCurrent Drug Targets - CNS & Neurological Disordersen_US
dc.subject.keywordHearing disordersen_US
dc.subject.keywordCochleaen_US
dc.subject.keywordGrowth factorsen_US
dc.subject.keywordDeafnessen_US
dc.subject.keywordStem cells, Ear: Diseasesen_US
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