Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation

Title:
Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation
Authors:
Fritzsch, Bernd; Silos-Santiago, I.; Bianchi, Lynne M.; Fariñas, I.
Abstract:
Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation to the semicircular canals. Mice lacking NT-3 or its receptor, Trk C, show a severe reduction of spiral neurons in the basal turn of the cochlea. Mice lacking both BDNF and NT-3 or Trk B and Trk C, reportedly lose all innervation to the inner ear. These two neurotrophins and their associated receptors are necessary for the normal afferent innervation of the inner ear.
Citation:
Fritzsch, B., I. Silos-Santiago, L.M. Bianchi, and I. Fariñas. 1997. "Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation." Seminars in Cell & Developmental Biology 8: 277-284.
Publisher:
Elsevier
DATE ISSUED:
1997-04
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.1006/scdb.1997.0144
PERMANENT LINK:
http://hdl.handle.net/11282/309747

Full metadata record

DC FieldValue Language
dc.contributor.authorFritzsch, Bernden_US
dc.contributor.authorSilos-Santiago, I.en_US
dc.contributor.authorBianchi, Lynne M.en_US
dc.contributor.authorFariñas, I.en_US
dc.date.accessioned2013-12-23T16:16:59Zen
dc.date.available2013-12-23T16:16:59Zen
dc.date.issued1997-04en
dc.identifier.citationFritzsch, B., I. Silos-Santiago, L.M. Bianchi, and I. Fariñas. 1997. "Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation." Seminars in Cell & Developmental Biology 8: 277-284.en_US
dc.identifier.issn1084-9521en_US
dc.identifier.urihttp://hdl.handle.net/11282/309747en
dc.description.abstractTwo neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation to the semicircular canals. Mice lacking NT-3 or its receptor, Trk C, show a severe reduction of spiral neurons in the basal turn of the cochlea. Mice lacking both BDNF and NT-3 or Trk B and Trk C, reportedly lose all innervation to the inner ear. These two neurotrophins and their associated receptors are necessary for the normal afferent innervation of the inner ear.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.identifier.doi10.1006/scdb.1997.0144en_US
dc.subject.departmentNeuroscienceen_US
dc.titleEffects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervationen_US
dc.typearticleen_US
dc.identifier.journalSeminars in Cell & Developmental Biologyen_US
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