EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers

Title:
EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers
Authors:
Bianchi, Lynne M.; Gray, Neil A.
Abstract:
The Eph family of receptors and ligands has been implicated in a variety of developmental processes, including the provision of inhibitory guidance cues to developing nerve fibers. A unique property of the B class of receptors is that they are able to phosphorylate ephrin-B ligands, allowing for bi-directional, or reverse signalling. While most of the studies to date have focused on central nerve fibers, little is known about the role of Eph molecules in guiding nerve fibers of the peripheral nervous system. In the present study, ephrin-B1 was found to be highly expressed on developing peripheral nerve fibers including auditory and vestibular (statoacoustic) and dorsal root ganglion nerve fibers. In vitro assays revealed that EphB-Fc receptors inhibited further growth of statoacoustic nerve fibers. In contrast, EphA7-Fc and ephrin-B2-Fc did not prevent further growth of SAG. Together, these results suggest a role for EphB receptors in providing guidance signals to ephrin-B1-positive SAG nerve fibers.
Citation:
Bianchi, L.M., and N.A. Gray. 2002. "EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers." European Journal of Neuroscience 16(8): 1499-1506.
Publisher:
Wiley-Blackwell
DATE ISSUED:
2002-10-01
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.1046/j.1460-9568.2002.02248.x
PERMANENT LINK:
http://hdl.handle.net/11282/309744

Full metadata record

DC FieldValue Language
dc.contributor.authorBianchi, Lynne M.en_US
dc.contributor.authorGray, Neil A.en_US
dc.date.accessioned2013-12-23T16:16:55Zen
dc.date.available2013-12-23T16:16:55Zen
dc.date.issued2002-10-01en
dc.identifier.citationBianchi, L.M., and N.A. Gray. 2002. "EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers." European Journal of Neuroscience 16(8): 1499-1506.en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.urihttp://hdl.handle.net/11282/309744en
dc.description.abstractThe Eph family of receptors and ligands has been implicated in a variety of developmental processes, including the provision of inhibitory guidance cues to developing nerve fibers. A unique property of the B class of receptors is that they are able to phosphorylate ephrin-B ligands, allowing for bi-directional, or reverse signalling. While most of the studies to date have focused on central nerve fibers, little is known about the role of Eph molecules in guiding nerve fibers of the peripheral nervous system. In the present study, ephrin-B1 was found to be highly expressed on developing peripheral nerve fibers including auditory and vestibular (statoacoustic) and dorsal root ganglion nerve fibers. In vitro assays revealed that EphB-Fc receptors inhibited further growth of statoacoustic nerve fibers. In contrast, EphA7-Fc and ephrin-B2-Fc did not prevent further growth of SAG. Together, these results suggest a role for EphB receptors in providing guidance signals to ephrin-B1-positive SAG nerve fibers.en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.identifier.doi10.1046/j.1460-9568.2002.02248.xen
dc.subject.departmentNeuroscienceen_US
dc.titleEphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibersen_US
dc.typearticleen_US
dc.identifier.journalEuropean Journal of Neuroscienceen_US
dc.subject.keywordCochleaen_US
dc.subject.keywordGuidanceen_US
dc.subject.keywordVestibular nerve fibersen_US
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