EphB2 guides axons at the midline and is necessary for normal vestibular function

Title:
EphB2 guides axons at the midline and is necessary for normal vestibular function
Authors:
Cowan, Chad A.; Yokoyama, Nobuhiko; Bianchi, Lynne M.; Henkemeyer, Mark; Fritzsch, Bernd
Abstract:
Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-filled lumen of the semicircular canals is severely reduced. EphB2 is expressed in the endolymph-producing dark cells in the inner ear epithelium, and these cells show ultrastructural defects in the mutants. A molecular link to fluid regulation is provided by demonstrating that PDZ domain–containing proteins that bind the C termini of EphB2 and B-ephrins can also recognize the cytoplasmic tails of anion exchangers and aquaporins. This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water.
Citation:
Cowan, C., N. Yokoyama, L.M. Bianchi, M. Henkemeyer, and B. Fritzsch. 2000. "EphB2 guides axons at the midline and is necessary for normal vestibular function." Neuron 26(2): 417-430.
Publisher:
Elsevier (Cell Press)
DATE ISSUED:
2000-05-01
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.1016/S0896-6273(00)81174-5
PERMANENT LINK:
http://hdl.handle.net/11282/309738

Full metadata record

DC FieldValue Language
dc.contributor.authorCowan, Chad A.en_US
dc.contributor.authorYokoyama, Nobuhikoen_US
dc.contributor.authorBianchi, Lynne M.en_US
dc.contributor.authorHenkemeyer, Marken_US
dc.contributor.authorFritzsch, Bernden_US
dc.date.accessioned2013-12-23T16:16:39Zen
dc.date.available2013-12-23T16:16:39Zen
dc.date.issued2000-05-01en
dc.identifier.citationCowan, C., N. Yokoyama, L.M. Bianchi, M. Henkemeyer, and B. Fritzsch. 2000. "EphB2 guides axons at the midline and is necessary for normal vestibular function." Neuron 26(2): 417-430.en_US
dc.identifier.issn0896-6273en_US
dc.identifier.urihttp://hdl.handle.net/11282/309738en
dc.description.abstractMice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-filled lumen of the semicircular canals is severely reduced. EphB2 is expressed in the endolymph-producing dark cells in the inner ear epithelium, and these cells show ultrastructural defects in the mutants. A molecular link to fluid regulation is provided by demonstrating that PDZ domain–containing proteins that bind the C termini of EphB2 and B-ephrins can also recognize the cytoplasmic tails of anion exchangers and aquaporins. This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water.en_US
dc.language.isoen_USen_US
dc.publisherElsevier (Cell Press)en_US
dc.identifier.doi10.1016/S0896-6273(00)81174-5en_US
dc.subject.departmentNeuroscienceen_US
dc.titleEphB2 guides axons at the midline and is necessary for normal vestibular functionen_US
dc.typearticleen_US
dc.identifier.journalNeuronen_US
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