Analysis of BDNF production in the aging gerbil cochlea

Title:
Analysis of BDNF production in the aging gerbil cochlea
Authors:
Medd, Amy M.; Bianchi, Lynne M.
Abstract:
Degeneration of cochlear neurons is the most commonly observed cellular change in the aging human and gerbil cochlea. Although it is unclear what leads to this neuronal loss, changes in the production of target-derived trophic factors may be the ultimate cause of cochlear neuron degeneration. The present study used an enzyme-linked immunosorbent assay to investigate whether BDNF is produced by the organ of Corti or cochlear ganglia of young, middle aged, or aged gerbils. The results revealed an age-related increase in BDNF in the organ of Corti, but not in the cochlear ganglia.
Citation:
Medd, A.M. and L.M. Bianchi. 2000. "Analysis of BDNF production in the aging gerbil cochlea." Experimental Neurology 162(2): 390-393.
Publisher:
Elsevier
DATE ISSUED:
2000-04
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.1006/exnr.2000.7353
PERMANENT LINK:
http://hdl.handle.net/11282/309737

Full metadata record

DC FieldValue Language
dc.contributor.authorMedd, Amy M.en_US
dc.contributor.authorBianchi, Lynne M.en_US
dc.date.accessioned2013-12-23T16:16:38Zen
dc.date.available2013-12-23T16:16:38Zen
dc.date.issued2000-04en
dc.identifier.citationMedd, A.M. and L.M. Bianchi. 2000. "Analysis of BDNF production in the aging gerbil cochlea." Experimental Neurology 162(2): 390-393.en_US
dc.identifier.issn0014-4886en_US
dc.identifier.urihttp://hdl.handle.net/11282/309737en
dc.description.abstractDegeneration of cochlear neurons is the most commonly observed cellular change in the aging human and gerbil cochlea. Although it is unclear what leads to this neuronal loss, changes in the production of target-derived trophic factors may be the ultimate cause of cochlear neuron degeneration. The present study used an enzyme-linked immunosorbent assay to investigate whether BDNF is produced by the organ of Corti or cochlear ganglia of young, middle aged, or aged gerbils. The results revealed an age-related increase in BDNF in the organ of Corti, but not in the cochlear ganglia.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.identifier.doi10.1006/exnr.2000.7353en_US
dc.subject.departmentNeuroscienceen_US
dc.titleAnalysis of BDNF production in the aging gerbil cochleaen_US
dc.typearticleen_US
dc.identifier.journalExperimental Neurologyen_US
dc.subject.keywordInner earen_US
dc.subject.keywordOrgan of Cortien_US
dc.subject.keywordSpiral gangliaen_US
dc.subject.keywordCochlear gangliaen_US
dc.subject.keywordNeurotrophinen_US
dc.subject.keywordBrain-derived neurotrophic factoren_US
dc.subject.keywordELISAen_US
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