Distribution of Eph-related molecules in the developing and mature cochlea

Title:
Distribution of Eph-related molecules in the developing and mature cochlea
Authors:
Bianchi, Lynne M.; Gale, N.W.
Abstract:
Receptors and ligands of the Eph family have recently been shown to influence the development of a variety of tissues. In the present study, the temporal and spatial distribution of Eph receptors and ligands were investigated in the embryonic and postnatal cochlea using Northern blot and immunohistochemical analysis. The results of Northern blot experiments revealed that a large number of Eph family members were present in embryonic cochlear and vestibular ganglia. Immunohistochemical studies revealed that ligands and receptors of the GPI subclass were distributed in complementary patterns within the differentiating spiral limbus, inner sulcus and outer sulcus. The distribution of these molecules became more restricted beginning in the first postnatal week. In contrast, members of the transmembrane subclass of Eph ligands were largely associated with cochlear neurons and their target hair cells. Expression of these ligands appeared to increase during the second postnatal week, corresponding to the period of peripheral nerve fiber reorganization in the cochlea. Together, these studies suggest that multiple Eph family members play unique roles in formation of the cochlea.
Citation:
Bianchi, L.M., and N.W. Gale. 1998. "Distribution of Eph-related molecules in the developing and mature cochlea." Hearing Research 117(1-2): 161-172.
Publisher:
Elsevier
DATE ISSUED:
1998-03
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.1016/S0378-5955(98)00010-0
PERMANENT LINK:
http://hdl.handle.net/11282/309735

Full metadata record

DC FieldValue Language
dc.contributor.authorBianchi, Lynne M.en_US
dc.contributor.authorGale, N.W.en_US
dc.date.accessioned2013-12-23T16:16:36Zen
dc.date.available2013-12-23T16:16:36Zen
dc.date.issued1998-03en
dc.identifier.citationBianchi, L.M., and N.W. Gale. 1998. "Distribution of Eph-related molecules in the developing and mature cochlea." Hearing Research 117(1-2): 161-172.en_US
dc.identifier.issn0378-5955en_US
dc.identifier.urihttp://hdl.handle.net/11282/309735en
dc.description.abstractReceptors and ligands of the Eph family have recently been shown to influence the development of a variety of tissues. In the present study, the temporal and spatial distribution of Eph receptors and ligands were investigated in the embryonic and postnatal cochlea using Northern blot and immunohistochemical analysis. The results of Northern blot experiments revealed that a large number of Eph family members were present in embryonic cochlear and vestibular ganglia. Immunohistochemical studies revealed that ligands and receptors of the GPI subclass were distributed in complementary patterns within the differentiating spiral limbus, inner sulcus and outer sulcus. The distribution of these molecules became more restricted beginning in the first postnatal week. In contrast, members of the transmembrane subclass of Eph ligands were largely associated with cochlear neurons and their target hair cells. Expression of these ligands appeared to increase during the second postnatal week, corresponding to the period of peripheral nerve fiber reorganization in the cochlea. Together, these studies suggest that multiple Eph family members play unique roles in formation of the cochlea.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.identifier.doi10.1016/S0378-5955(98)00010-0en_US
dc.subject.departmentNeuroscienceen_US
dc.titleDistribution of Eph-related molecules in the developing and mature cochleaen_US
dc.typearticleen_US
dc.identifier.journalHearing Researchen_US
dc.subject.keywordInner earen_US
dc.subject.keywordAuditoryen_US
dc.subject.keywordEphrinen_US
dc.subject.keywordGerbilen_US
dc.identifier.volume117en_US
dc.identifier.issue1-2en_US
dc.identifier.startpage161en_US
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