Effects of prenatal androgens on rhesus monkeys: A model system to explore the organizational hypothesis in primates

Title:
Effects of prenatal androgens on rhesus monkeys: A model system to explore the organizational hypothesis in primates
Authors:
Thornton, Janice E.; Zehr, Julia L.; Loose, Michael D.
Abstract:
After proposing the organizational hypothesis from research in prenatally androgenized guinea pigs (Phoenix, C.H., Goy, R.W., Gerall, A.A., Young, W.C., 1959. Organizational action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65, 369–382.), the same authors almost immediately extended the hypothesis to a nonhuman primate model, the rhesus monkey. Studies over the last 50 years have verified that prenatal androgens have permanent effects in rhesus monkeys on the neural circuits that underlie sexually dimorphic behaviors. These behaviors include both sexual and social behaviors, all of which are also influenced by social experience. Many juvenile behaviors such as play, mounting, and vocal behaviors are masculinized and/or defeminized, and aspects of adult sexual behavior are both masculinized (e.g. approaches, sex contacts, and mounts) and defeminized (e.g. sexual solicits). Different behavioral endpoints have different periods of maximal susceptibility to the organizing actions of prenatal androgens. Aromatization is not important, as both testosterone and dihydrotestosterone are equally effective in rhesus monkeys. Although the full story of the effects of prenatal androgens on sexual and social behaviors in the rhesus monkey has not yet completely unfolded, much progress has been made. Amazingly, a large number of the inferences drawn from the original 1959 study have proved applicable to this nonhuman primate model.
Citation:
Thornton, J., J. Zehr, and M. D. Loose. 2009. "Effects of prenatal androgens on rhesus monkeys: A model system to explore the organizational hypothesis in primates." Hormones And Behavior 55(5): 633-645.
Publisher:
Elsevier
DATE ISSUED:
2009
Department:
Neuroscience
Type:
article
PUBLISHED VERSION:
10.1016/j.yhbeh.2009.03.015
PERMANENT LINK:
http://hdl.handle.net/11282/309578

Full metadata record

DC FieldValue Language
dc.contributor.authorThornton, Janice E.en_US
dc.contributor.authorZehr, Julia L.en_US
dc.contributor.authorLoose, Michael D.en_US
dc.date.accessioned2013-12-23T16:12:36Zen
dc.date.available2013-12-23T16:12:36Zen
dc.date.issued2009en
dc.identifier.citationThornton, J., J. Zehr, and M. D. Loose. 2009. "Effects of prenatal androgens on rhesus monkeys: A model system to explore the organizational hypothesis in primates." Hormones And Behavior 55(5): 633-645.en_US
dc.identifier.issn0018-506Xen_US
dc.identifier.urihttp://hdl.handle.net/11282/309578en
dc.description.abstractAfter proposing the organizational hypothesis from research in prenatally androgenized guinea pigs (Phoenix, C.H., Goy, R.W., Gerall, A.A., Young, W.C., 1959. Organizational action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65, 369–382.), the same authors almost immediately extended the hypothesis to a nonhuman primate model, the rhesus monkey. Studies over the last 50 years have verified that prenatal androgens have permanent effects in rhesus monkeys on the neural circuits that underlie sexually dimorphic behaviors. These behaviors include both sexual and social behaviors, all of which are also influenced by social experience. Many juvenile behaviors such as play, mounting, and vocal behaviors are masculinized and/or defeminized, and aspects of adult sexual behavior are both masculinized (e.g. approaches, sex contacts, and mounts) and defeminized (e.g. sexual solicits). Different behavioral endpoints have different periods of maximal susceptibility to the organizing actions of prenatal androgens. Aromatization is not important, as both testosterone and dihydrotestosterone are equally effective in rhesus monkeys. Although the full story of the effects of prenatal androgens on sexual and social behaviors in the rhesus monkey has not yet completely unfolded, much progress has been made. Amazingly, a large number of the inferences drawn from the original 1959 study have proved applicable to this nonhuman primate model.en_US
dc.publisherElsevieren_US
dc.identifier.doi10.1016/j.yhbeh.2009.03.015en
dc.subject.departmentNeuroscienceen_US
dc.titleEffects of prenatal androgens on rhesus monkeys: A model system to explore the organizational hypothesis in primatesen_US
dc.typearticleen_US
dc.identifier.journalHormones And Behavioren_US
dc.identifier.volume55en_US
dc.identifier.issue5en_US
dc.identifier.startpage633en_US
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